Herding Hemingway's Cats by
The language of genes has become common parlance. We know they make our eyes blue, our hair curly, and they control our risks of cancer, heart disease, alcoholism, and Alzheimer's. One thousand dollars will buy you your own genome readout, neatly stored on a USB stick. And advances in genetic medicine hold huge promise. We've all heard of genes, buthow do they actually work? There are six feet of DNA inside every one of your cells; this encodes 20,000 or so genes, tangled into a mass of molecular spaghetti. This is the text of the cookbook of life, and hidden within these strands are the instructions that tell cells when and where to turn genes on or off. In 1935, Ernest Hemingway was supposedly given Snow White, a six-toed cat who went on to father a line of similar offspring that still roam the writer's Florida estate. Scientists now know that the fault driving this profusion of digits lies in a tiny genetic control switch, miles away (in molecular terms) from the gene that "makes" toes. Researchers are discovering more about the myriad molecular switches that make sure genes are turned on at the right time and in the right place, and what happens when they don't work properly. This is allowing a four-dimensional picture of DNA to be built--a dynamic biological library, rather than static strings of code. Geneticist Kat Arney explores the intricacies of how, out of this seeming genetic chaos, life is created.
Human Genome : a User's Guide by
Significant advances in our knowledge of genetics were made during the twentieth century but in the most recent decades, genetic research has dramatically increased its impact throughout society. Genetic issues are now playing a large role in health and public policy, and new knowledge in this field will continue to have significant implications for individuals and society. Written for the non-majors human genetics course, Human Genetics, 3E will increase the genetics knowledge of students who are learning about human genetics for the first time. This thorough revision of the best-selling Human Genome,2E includes entirely new chapters on forensics, stem cell biology, bioinformatics, and societal/ethical issues associated with the field. New special features boxes make connections between human genetics and human health and disease. Carefully crafted pedagogy includes chapter-opening case studies that set the stage for each chapter; concept statements interspersed throughout the chapter that keep first-time students focused on key concepts; and end-of-chapter questions and critical thinking activities. This new edition will contribute to creating a genetically literate student population that understands basic biological research, understands elements of the personal and health implications of genetics, and participates effectively in public policy issues involving genetic information . Includes topical material on forensics, disease studies, and the human genome project to engage non-specialist students Full, 4-color illustration program enhances and reinforces key concepts and themes Uniform organization of chapters includes interest boxes that focus on human health and disease, chapter-opening case studies, and concept statements to engage non-specialist readers
Genetic Disorders Sourcebook by
Child Abuse Sourcebook, Second Edition provides updated information about neglect and physical, emotional, and sexual abuse of children and adolescents. These include abusive head trauma, Munchausen syndrome by proxy, corporal punishment, bullying, aggression through technology, child exploitation, teen dating abuse, and parental substance abuse. Guidelines are provided on how to report abuse and who must report abuse. Information about the legal protections available through Child Protective Services, the court system, foster care, and adoption is described. Abuse prevention programs that provide education, respite and crisis care, and support groups for children, teens, adults, and communities are presented. A section on strategies for positive parenting discusses child discipline, anger management, leaving children home alone, and helping children who have been sexually abused. A glossary of related terms and directories of additional resources are also includ
Am I My Genes? Confronting Fate and Family Secrets in the Age of Genetic Testing by
In the fifty years since DNA was discovered, we have seen extraordinary advances. For example, genetic testing has rapidly improved the diagnosis and treatment of diseases such as Huntington's, cystic fibrosis, breast cancer, and Alzheimer's. But with this new knowledge comes difficultdecisions for countless people, who wrestle with fear about whether to get tested, and if so, what to do with the results. Am I My Genes? shows how real individuals have confronted these issues in their daily lives. Robert L. Klitzman interviewed 64 people who faced Huntington's Disease, breast and ovarian cancer, or Alpha-1 antitrypsin deficiency. The book describes - often in the person's own words - how each haswrestled with the vast implications that genetics has for their lives and their families. Klitzman shows how these men and women struggle to make sense of their predicament and its causes. They confront a series of quandaries - whether to be tested; whether to disclose their genetic risks toparents, siblings, spouses, offspring, friends, doctors, insurers, employers, and schools; how to view and understand themselves and their genetics; what treatments, if any, to pursue; whether to have children, adopt, screen embryos, or abort; and whether to participate in genetic communities. In the face of these uncertainties, they have tried to understand these tests and probabilities, avoid fatalism, anxiety, despair, and discrimination, and find hope, meaning, and a sense of wholeness. Forced to wander through a wilderness of shifting sands, they chart paths that many others mayeventually follow. Klitzman captures here the voices of pioneers, some of the first to encounter the personal dilemmas introduced by modern genetics. Am I My Genes? is an invaluable account of their experience, one that will become all the more common in the coming years.
Genetics by
This illustrated book on genetics contains new objective-type questions and over 450 solved problems and includes chapters on the physical basis of heredity, single gene inheritance, the genetics of sex and linkage and chromosome mapping.
A lot of science research is freely available. See below for some good websites to help locate these resources:
Bar Code of Life Data Systems (BOLD) is an online workbench that aids collection, management, analysis, and use of DNA barcodes. It consists of 3 components (MAS, IDS, and ECS) that each address the needs of various groups in the barcoding community.
Bar Code of Life Data Systems (BOLD) Identification Engine The BOLD Identification System (IDS) accepts sequences from the 5' region of the mitochondrial gene COI and returns a species-level identification when one is
possible. Further validation with independent genetic markers will be desirable in some forensic applications.
EMBL - European Bioinformatics Institute
Entrez databases from National Center for Biotechnology Information NCBI
National Center for Biotechnological Information (NCBI) from National Library of Medicine (includes GeneBank, Entrez, Cancer Genome Database, Human Genome Database, etc.)
National Center for Biotechnology Information (NCBI) Handbook
OMIM, Online Mendelian Inheritance in Man
Comparative Gene Finding
ECR-Browser.
eShadow.
zPicture.
UCSC genome browser. -- Current Annotations for the Genomic DNA Sequences
GenomeWeb
Human Genome Project (HGP) coordinated by the U.S> Dept. of Energy and the National Institutes of Health.
National Institutes of Health (NIH). Roadmap for Medical Research. Epigenomics Program.
National Institutes of Health (NIH) Roadmap for Medical Research. Structural Biology.
Protein Data Bank An Information Portal to Biological Macromolecular Structures from the Research Collaboratory for Structural Bioinformatics (RSCB). "The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies ... [and can be used to do] ... simple and advanced searches based on annotations relating to sequence, structure and function" Summaries include parameters, unit cell, classification, classification, images and visulaization KiNG, Jmol, WebMol, Rasmol, etc.), and more. Each structure summary includes PubMed's Medical Subject Headings (MeSH) !!